Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

Sklar, P., Schwab, S. G., Williams, Nigel Melville ORCID: https://orcid.org/0000-0003-1177-6931, Daly, M., Schaffner, S., Maier, W., Albus, M., Trixler, M., Eichhammer, P., Lerer, B., Hallmayer, J., Norton, N., Williams, H., Zammit, Stanley ORCID: https://orcid.org/0000-0002-2647-9211, Cardno, A. G., Jones, S. and McCarthy, G. 2001. Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls. Nature Genetics 28 (2) , pp. 126-128. 10.1038/88836

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Abstract

A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Nature Publishing Group
ISSN:	1061-4036
Last Modified:	31 Oct 2022 09:22
URI:	https://orca.cardiff.ac.uk/id/eprint/80790

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