A case-control study of family history and cerebral cortical abnormalities in schizophrenia

Jones, P. B., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Lewis, S. W. and Murray, R. M. 1993. A case-control study of family history and cerebral cortical abnormalities in schizophrenia. Acta Psychiatrica Scandinavica 87 (1) , pp. 6-12. 10.1111/j.1600-0447.1993.tb03322.x

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Abstract

The relationship between family history of psychosis and cortical sulcal widening on CT scans was investigated. Forty-two schizophrenic subjects with a positive family history were individually matched to 42 schizophrenics with no documented family history and 42 healthy controls. Abnormally wide sulci, as defined on the basis of the normal control data, were significantly more common in the family history negative group (9/42) than in the family history positive group (1/42) or the controls (2/36). No significant correlation was found between cerebral cortical ratings and ventricular size.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Wiley-Blackwell
ISSN:	0001-690X
Last Modified:	31 Oct 2022 09:23
URI:	https://orca.cardiff.ac.uk/id/eprint/80844

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