Searching for schizophrenia genes

Bray, Nicholas John ORCID: https://orcid.org/0000-0002-4357-574X and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 2001. Searching for schizophrenia genes. Trends in Molecular Medicine 7 (4) , pp. 169-174.

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Abstract

Schizophrenia is characterized by profound disturbances of cognition, emotion and social functioning. It carries a lifetime risk within the general population of approximately 1%. Genetic epidemiological studies have shown that the syndrome has a high heritability, indicating a significant genetic component to its aetiology. However, the undoubted complexity and probable heterogeneity of the disorder continue to confound research, and the precise underlying neurobiological mechanisms remain largely unknown. Although molecular-genetic approaches face formidable difficulties, the identification of susceptibility genes is likely to provide valuable insights into the aetiology and pathogenesis that could lead to the development of more effective treatments.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Elsevier
ISSN:	1471-4914
Last Modified:	31 Oct 2022 09:23
URI:	https://orca.cardiff.ac.uk/id/eprint/80854

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