Hibernated human fetal striatal tissue: successful transplantation in a rat model of Huntington's disease

Hurelbrink, C. B., Armstrong, R. J., Barker, R. A., Dunnett, S. B. and Rosser, Anne Elizabeth ORCID: https://orcid.org/0000-0002-4716-4753 2000. Hibernated human fetal striatal tissue: successful transplantation in a rat model of Huntington's disease. Cell Transplantation 9 (6) , pp. 743-749.

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Abstract

The use of fresh human fetal tissue in neural transplantation presents considerable logistical difficulties and limits the clinical applicability of this promising therapy. This study compared the survival of human fetal striatal tissue that had been stored for 24 h in a defined hibernation medium with that of fresh human fetal striatal tissue following xenotransplantation in a rat model of Huntington's disease (HD). Six to 7 weeks postgrafting, there was no significant difference between fresh and hibernated grafts in volume or in various striatal phenotypic markers, although there was a trend towards decreased graft volume. We conclude that short-term hibernation of this tissue is without significant adverse effects on the survival of grafted human fetal striatal tissue. This has important implications for the practical implementation of clinical neural transplant programs in HD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	1999- : Elmsford, NY : Cognizant Communication
ISSN:	0963-6897
Last Modified:	31 Oct 2022 09:26
URI:	https://orca.cardiff.ac.uk/id/eprint/81011

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