Nanomechanical and surface properties of rMSCs post exposure to CAP treated UHMWPE wear particles

Preedy, Emily Callard, Perni, Stefano and Prokopovich, Polina ORCID: https://orcid.org/0000-0002-5700-9570 2016. Nanomechanical and surface properties of rMSCs post exposure to CAP treated UHMWPE wear particles. Nanomedicine: Nanotechnology, Biology and Medicine 12 (3) , pp. 723-734. 10.1016/j.nano.2015.10.006

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Abstract

Wear debris generated by ultra-high molecular weight polyethylene (UHMWPE) used in joint replacement devices has been of concern due to reductions of the implant longevity. Cold atmospheric plasma (CAP) has been used to improve the wear performance of UHMWPE. The aim of this study was to investigate the elastic and adhesive properties of rat mesenchymal stem cells (rMSCs), through AFM, after exposure to UHMWPE wear debris pre and post CAP treatment. The result indicated that the main changes in cell elasticity and spring constant of MSC exposed to wear particles occurred in the first 24 hour of contact and the particles concentration from 0.5 to 50 mg/l did not play a significant role. For UHMWPE treated for 7.5 min, with progression of the wear simulation the results of the CAP treated samples were getting closer to the result of untreated samples; whilst with longer CAP treatment this was not observed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Publisher:	Elsevier
ISSN:	1549-9634
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	22 October 2015
Last Modified:	05 May 2023 09:54
URI:	https://orca.cardiff.ac.uk/id/eprint/81013

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