Coordinated regulation of synaptic plasticity at striatopallidal and sriatonigral neurons orchestrates motor control

Trusel, Massimo, Cavaccini, Anna, Gritti, Marta, Greco, Barbara, Saintot, Pierre-Philippe, Nazzaro, Cristiano, Cerovic, Milica, Morella, Ilaria ORCID: https://orcid.org/0000-0001-5691-5400, Brambilla, Riccardo ORCID: https://orcid.org/0000-0003-3569-5706 and Tonini, Raffaella 2015. Coordinated regulation of synaptic plasticity at striatopallidal and sriatonigral neurons orchestrates motor control. Cell Reports 13 (7) , pp. 1353-1365. 10.1016/j.celrep.2015.10.009

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Abstract

The basal ganglia play a critical role in shaping motor behavior. For this function, the activity of medium spiny neurons (MSNs) of the striatonigral and striatopallidal pathways must be integrated. It remains unclear whether the activity of the two pathways is primarily coordinated by synaptic plasticity mechanisms. Using a model of Parkinson’s disease, we determined the circuit and behavioral effects of concurrently regulating cell-type-specific forms of corticostriatal long-term synaptic depression (LTD) by inhibiting small-conductance Ca2+-activated K+ channels (SKs) of the dorsolateral striatum. At striatopallidal synapses, SK channel inhibition rescued the disease-linked deficits in endocannabinoid (eCB)-dependent LTD. At striatonigral cells, inhibition of these channels counteracted a form of adenosine-mediated LTD by activating the ERK cascade. Interfering with eCB-, adenosine-, and ERK signaling in vivo alleviated motor abnormalities, which supports that synaptic modulation of striatal pathways affects behavior. Thus, our results establish a central role of coordinated synaptic plasticity at MSN subpopulations in motor control.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Additional Information:	This is an open access article under the terms of the CC-BY license.
Publisher:	Elsevier
ISSN:	2211-1247
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	4 October 2015
Last Modified:	06 May 2023 10:33
URI:	https://orca.cardiff.ac.uk/id/eprint/81146

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