Family history and cerebral ventricular enlargement in schizophrenia. A case control study

Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Lewis, S. W. and Murray, R. M. 1989. Family history and cerebral ventricular enlargement in schizophrenia. A case control study. British Journal of Psychiatry 154 (5) , pp. 629-634. 10.1192/bjp.154.5.629

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Abstract

Ventricular size was measured from CT scans in 48 patients meeting RDC for schizophrenia who had a first-degree relative with a history of treatment for major psychiatric disorder, in 48 age- and sex-matched schizophrenic patients with no such history in first- or second-degree relatives, and in 48 matched, healthy controls. There was no difference in ventricular size between those with and without a positive family history, although both groups showed ventricular enlargement with respect to normal controls. Ventricular enlargement was demonstrated in the subgroup of 23 patients with a family history of schizophrenia, but not in the subgroup of 18 patients with a family history of affective disorder. These observations provide further evidence that schizophrenics with a family history of affective disorder may constitute an aetiologically distinct subgroup.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Royal College of Psychiatrists
ISSN:	0007-1250
Last Modified:	31 Oct 2022 09:28
URI:	https://orca.cardiff.ac.uk/id/eprint/81180

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