Genetic basis of attention deficit and hyperactivity

Thapar, Anita ORCID: https://orcid.org/0000-0002-3689-737X, Holmes, J., Poulton, K. and Harrington, R. 1999. Genetic basis of attention deficit and hyperactivity. British Journal of Psychiatry 174 , pp. 105-111. 10.1192/bjp.174.2.105

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Abstract

BACKGROUND: Hyperkinetic disorder or attention-deficit hyperactivity disorder (ADHD) is an important clinical condition. AIMS: The research evidence for a genetic contribution to ADHD is reviewed. METHOD: Measurement of the phenotype, the extent to which attention deficit and hyperactivity are heritable and molecular genetic findings are discussed. Future research directions are also considered. RESULTS: ADHD is a familial disorder. Available adoption evidence suggests genetic influences are important. Twin studies have primarily focused on trait measures which have consistently been found to be highly heritable Molecular genetic studies of clinical disorder so far have suggested the involvement of the dopamine DRD-4 receptor gene and dopamine transporter gene (DAT1). However, these findings await further replication. CONCLUSIONS: Advances in psychiatric genetics and current research interest in the genetics of ADHD should improve our understanding of aetiological factors and have an impact on treatment.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Royal College of Psychiatrists
ISSN:	0007-1250
Last Modified:	31 Oct 2022 09:32
URI:	https://orca.cardiff.ac.uk/id/eprint/81477

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