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Affected sib-pair methods for detecting linkage to dichotomous traits: review of the methodology

Holmans, Peter Alan 1998. Affected sib-pair methods for detecting linkage to dichotomous traits: review of the methodology. Human biology 70 (6) , pp. 1025-1040.

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Abstract

Affected sib-pair methods are commonly used to detect linkage to dichotomous traits. This review discusses the principles underlying affected sib-pair tests for linkage and the merits of sib-pair methods relative to traditional lod score methods. Extensions of the methods to include other typed unaffected relatives, extra affected siblings, and multiple marker and disease loci are reviewed together with an investigation of the most effective ways to perform genome scans.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Wayne State University Press
ISSN: 0018-7143
Last Modified: 02 May 2019 12:49
URI: http://orca.cardiff.ac.uk/id/eprint/81517

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