Genetic and environmental influences on drug use and abuse/dependence in male and female twins

van den Bree, Marianne Bernadette ORCID: https://orcid.org/0000-0002-4426-3254, Johnson, E. O., Neale, M. C. and Pickens, R. W. 1998. Genetic and environmental influences on drug use and abuse/dependence in male and female twins. Drug and Alcohol Dependence 52 (3) , pp. 231-241. 10.1016/S0376-8716(98)00101-X

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Abstract

Twins were recruited through alcohol and drug treatment programs. With structural equation modeling, genetic and environmental estimates were obtained for use and DSM-III abuse/dependence of sedatives, opioids, cocaine, stimulants, and cannabis as well as any illicit drug. Analyses were conducted separately for males and females. Models included thresholds based on population prevalence of use or abuse/dependence and ever having been in treatment. Genetic influences were found for most measures. They were generally stronger for males than females and for clinical diagnoses of abuse/dependence compared to use. Common environmental influences played a greater role in use than abuse/dependence.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Elsevier
ISSN:	0376-8716
Last Modified:	31 Oct 2022 09:34
URI:	https://orca.cardiff.ac.uk/id/eprint/81566

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