Polydactyly and psychosis. Five cases of co-occurrence

Cardno, A. G., Murphy, K. C., Jones, L. A., Cobb, A. M., Gray, J., McGuffin, P. and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 1998. Polydactyly and psychosis. Five cases of co-occurrence. British Journal of Psychiatry 172 , pp. 184-185. 10.1192/bjp.172.2.184

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Abstract

BACKGROUND: Abnormalities presumed to occur during foetal life have been associated with schizophrenia. Polydactyly is a developmental abnormality but no previous association has been reported between polydactyly and functional psychotic illness. METHOD: Individuals with both polydactyly and a functional psychosis were ascertained during a study of familial schizophrenia. RESULTS: Five such individuals were ascertained in the course of assessing 234 individuals with familial psychosis, giving a rate of polydactyly in the sample of around 10 times the general population rate. CONCLUSIONS: This study provides preliminary evidence that polydactyly is over-represented in individuals with familial schizophrenia and related psychotic illnesses.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Royal College of Psychiatrists
ISSN:	0007-1250
Last Modified:	31 Oct 2022 09:37
URI:	https://orca.cardiff.ac.uk/id/eprint/81747

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