Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD

Myers, Amanda J., Marshall, Helen, Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Compton, Danielle, Crook, Richard J.P., Mander, Adrian P., Nowotny, Petra, Smemo, Scott, Dunstan, Melanie ORCID: https://orcid.org/0000-0003-3817-2142, Jehu, Luke, Wang, Jen C., Hamshere, Marian Lindsay ORCID: https://orcid.org/0000-0002-8990-0958, Morris, John C., Norton, Joanne, Chakraventy, Sumi, Tunstall, Nigel, Lovestone, Simon, Petersen, Ronald, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379, Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612, Williams, Julie ORCID: https://orcid.org/0000-0002-4069-0259, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Hardy, John and Goate, Alison 2004. Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD. American Journal of Medical Genetics 124B (1) , pp. 29-37. 10.1002/ajmg.b.20036

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Abstract

Linkage studies indicate that the same region of chromosome 10 contains a risk locus for late onset Alzheimer disease (LOAD) and a QTL for plasma Abeta42 levels suggesting that a single locus may influence risk for AD by elevating plasma Abeta42 [Ertekin-Taner et al., 2000; Myers et al., 2000]. A strong positional and biological candidate is the urokinase-plasminogen activator (PLAU) gene. Eight polymorphisms spanning the entire gene were examined using case control (CC) and family-based association methods. No association was observed by any method making it unlikely that variation in PLAU explains our linkage data.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Wiley
ISSN:	0148-7299
Last Modified:	04 Mar 2023 03:01
URI:	https://orca.cardiff.ac.uk/id/eprint/81794

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