Unveiling the potential of prohibitin in cancer

Koushyar, Sarah, Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 and Dart, Dafydd Alwyn 2015. Unveiling the potential of prohibitin in cancer. Cancer Letters 369 (2) , pp. 316-322. 10.1016/j.canlet.2015.09.012

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Abstract

Recently, research has shed new light on the role of Prohibitin (PHB) in cancer pathogenesis across an array of cancer types. Important mechanisms for PHB have been unveiled in several cancers, especially with regard to the androgen independent state of prostate cancer (PC) and oestrogen dependent breast cancer. However, PHB is often overlooked due to its complex but subtle roles within the cell. Having gathered both historical and current research exploring PHB's role in different cancer types including prostate and breast, here we aim to pair this information with its molecular properties in the hope of translating this information into a clinical perspective, thus discussing its possible use in future cancer therapy.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	Prohibitin; Prostate cancer; Breast cancer; Cell cycle; Cancer therapy
Publisher:	Elsevier
ISSN:	0304-3835
Funders:	Cancer Research Wales
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	19 September 2015
Last Modified:	11 Oct 2023 18:50
URI:	https://orca.cardiff.ac.uk/id/eprint/82004

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