A linkage study of schizophrenia with DNA markers from chromosome 8p21-p22 in 25 multiplex families

Kunugi, H., Curtis, D., Vallada, H. P., Nanko, S., Powell, J. F., Murray, R. M., McGuffin, P., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Gill, M. and Collier, D. A. 1996. A linkage study of schizophrenia with DNA markers from chromosome 8p21-p22 in 25 multiplex families. Schizophrenia Research 22 (1) , pp. 61-68. 10.1016/0920-9964(96)00048-5

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Abstract

Two recent genome-wide searches for linkage (Lasseter et al., 1994; Moises et al., 1995) suggested that a susceptibility gene for schizophrenia might be located at chromosome 8p21-p22. We attempted to replicate these findings by performing a linkage study of schizophrenia with four DNA markers from this region using 25 multiply affected families. Neither the lod score method nor non-prametric extended sib-pair analysis yielded any evidence for linkage, even under the assumption of locus heterogeneity. We conclude that there is unlikely to be a major gene in the 8p21-p22 region which confers susceptibility to schizophrenia in our set of families. However we cannot exclude the possibility of a major gene present in other families, or of a susceptibility gene with a moderate but widespread effect which we cannot detect.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	0920-9964
Last Modified:	31 Oct 2022 09:40
URI:	https://orca.cardiff.ac.uk/id/eprint/82015

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