Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine

Arranz, M. J., Collier, D. A., Munro, J., Sham, P., Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, Sodhi, M., Roberts, G., Price, J. and Kerwin, R. W. 1996. Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine. Neuroscience Letters 217 (2-3) , pp. 177-178. 10.1016/0304-3940(96)13094-9

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Abstract

Clozapine is an atypical antipsychotic with affinity for a broad range of receptors, including serotonin (5-HT) and dopamine receptors. It is successful in treating about 60% of patients refractory to other antipsychotic drugs. Since genetic variation in clozapine's neurotransmitter receptor targets may affect clinical response through altering drug binding or receptor expression, we have studied a His452Tyr polymorphism in the 5-HT2A receptor (HTR2A) in a sample of 153 schizophrenic patients undergoing clozapine treatment and 178 normal controls. An association was found between the allele Tyr452 and poor clinical response.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier Scientific Publishers Ireland
ISSN:	0304-3940
Last Modified:	31 Oct 2022 09:40
URI:	https://orca.cardiff.ac.uk/id/eprint/82018

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