Relationship between disabling fatigue and depression in children: Genetic study

Fowler, T. A., Rice, Frances ORCID: https://orcid.org/0000-0002-9484-1729, Thapar, Anita ORCID: https://orcid.org/0000-0002-3689-737X and Farmer, Anne 2006. Relationship between disabling fatigue and depression in children: Genetic study. British Journal of Psychiatry 189 (3) , pp. 247-253. 10.1192/bjp.bp.105.011379

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Abstract

Background: Medically unexplained disabling fatigue in young people is familial and frequently associated with depressed mood. Aims: To examine the degree of sharing of genetic and environmental influences on the symptoms of depression and fatigue in this age group. Method: The parents of twins aged 8-17 years, derived from a population-based register, completed a questionnaire regarding lifetime-ever disabling fatigue in both twins. Twins aged 11 years or over completed the Mood and Feelings Questionnaire. The genetic and environmental influences on fatigue and the relationship with depression were examined using bivariate genetic analysis. Results: Parent-rated data were obtained for 1468 twin pairs (65%) and self-rated data from 930 older twin pairs (58%). Bivariate analysis of fatigue and depression suggested that genetic and environmental influences on disabling fatigue were mainly specific to fatigue. Conclusions: Unexplained disabling fatigue in childhood is substantially familial and has mainly an independent aetiology from depression

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Royal College of Psychiatrists
ISSN:	0007-1250
Last Modified:	31 Oct 2022 09:41
URI:	https://orca.cardiff.ac.uk/id/eprint/82049

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