Indicators of genetic and environmental influences in drug abusing individuals

Johnson, E. O., van den Bree, Marianne Bernadette ORCID: https://orcid.org/0000-0002-4426-3254, Uhl, G. R. and Pickens, R. W. 1996. Indicators of genetic and environmental influences in drug abusing individuals. Drug and Alcohol Dependence 41 (1) , pp. 17-23. 10.1016/0376-8716(96)01223-9

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Abstract

To assess relative contribution of genetic and environmental influences in individual cases of drug abuse/dependence, separate scales were constructed from DIS (version III) drug symptom items. Using data from 38 MZ and 35 DZ male twin pairs, items with significant MZ/DZ differences in probandwise concordance were assigned to a genetic scale whereas items without significant MZ/DZ differences were assigned to an environmental scale. As expected, significant differences were found between MZ and DZ twins in intraclass correlations for the genetic but not environmental scale. Genetic scores on drug and alcohol scales were correlated (r = 0.40), whereas environmental scales were not. When scores on the genetic scales were compared, the correlation between drug and alcohol scores within individuals was similar to that across MZ twins, both of which were higher than the correlation across DZ twins. These results suggest (1) relative contribution of genetic and environmental influences in individual cases of drug dependence can be assessed, and (2) common genetic mechanisms may be involved in alcohol and drug dependence.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	0376-8716
Last Modified:	31 Oct 2022 09:41
URI:	https://orca.cardiff.ac.uk/id/eprint/82096

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