Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32

Lin, M. W., Curtis, D., Williams, Nigel Melville ORCID: https://orcid.org/0000-0003-1177-6931, Arranz, M., Nanko, S., Collier, D., McGuffin, P., Murray, R., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 and Gill, M. 1995. Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32. Psychiatric Genetics 5 (3) , pp. 117-126. 10.1097/00041444-199505030-00004

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Abstract

Family, twin and adoption studies highlight the influence of genes in the aetiology of schizophrenia, though the mode of inheritance is unclear. We have been conducting a systematic search for major genes in schizophrenia using a series of multiply affected families and report preliminary results of linkage under heterogeneity with markers on chromosome 13. A lod2 score of 1.61 for marker D13S144 was obtained at theta = 0 and alpha of 0.5 and nearby markers also produced positive values.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Lippincott Williams & Wilkins
ISSN:	0955-8829
Last Modified:	17 Aug 2023 18:29
URI:	https://orca.cardiff.ac.uk/id/eprint/82201

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