Association between a promoter variant in the monoamine oxidase A gene and schizophrenia

Jönsson, Erik G., Norton, Nadine, Forslund, Kaj, Mattila-Evenden, Marja, Rylander, Gunnar, Åsberg, Marie, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 and Sedvall, Göran C. 2003. Association between a promoter variant in the monoamine oxidase A gene and schizophrenia. Schizophrenia Research 61 (1) , pp. 31-37. 10.1016/S0920-9964(02)00224-4

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Abstract

Monoaminergic transmission has been implicated in the pathophysiology of schizophrenia. We investigated a putative functional promoter polymorphism in the monoamine oxidase A (MAOA) gene in schizophrenic patients (n=133) and control subjects (n=377). In men, there was an association between the less efficiently transcribed alleles and schizophrenia (chi(2)=4.01, df=1, p<0.05). In women, no significant differences were found. The present results support the involvement of the MAOA gene in men with schizophrenia in the investigated Swedish population but should be interpreted with caution until replicated.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	0920-9964
Last Modified:	31 Oct 2022 09:45
URI:	https://orca.cardiff.ac.uk/id/eprint/82335

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