Dopamine transporter gene (DAT1) VNTR polymorphism in major psychiatric disorders: family-based association study in the Bulgarian population

Georgieva, Lyudmila, Dimitrova, A., Nikolov, I., Koleva, S., Tsvetkova, R., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Toncheva, D. and Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950 2002. Dopamine transporter gene (DAT1) VNTR polymorphism in major psychiatric disorders: family-based association study in the Bulgarian population. Acta Psychiatrica Scandinavica 105 (5) , pp. 396-399. 10.1034/j.1600-0447.2002.1o174.x

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Abstract

Objective: A 40-bp variable number tandem repeat in the 3′-UTR of dopamine transporter gene (DAT1) has been examined for association with major psychiatric disorders in several case–control studies. No significant results have been found. We used a new collection of parent–offspring trios to test for association with schizophrenia (SZ), bipolar 1 disorder (BPI) and schizoaffective (SA) disorder. Method: We genotyped trios from Bulgarian origin where the proband had SZ (178 trios), BPI (77 trios) and SA (29 trios). Alleles ranging from 5 to 11 repeats were observed. The results were analysed with the extended TDT (ETDT). Results: No preferential transmission of alleles was observed for any diagnostic group. The presence of allele DAT*10 was associated with the severity and frequency of auditory hallucinations, however, this result is not significant if corrected for multiple testing. Conclusion: Our results are in agreement with previous reports of a lack of association between this polymorphism and major psychiatric disorders.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Wiley-Blackwell
ISSN:	0001-690X
Last Modified:	31 Oct 2022 09:47
URI:	https://orca.cardiff.ac.uk/id/eprint/82475

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