A Quantitative Trait Locus Associated With Cognitive Ability in Children

Chorney, M.J., Chorney, K., Seese, N., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Daniels, J., McGuffin, P., Thompson, L.A., Detterman, D.K., Benbow, C., Lubinski, D., Eley, T. and Plomin, R. 1998. A Quantitative Trait Locus Associated With Cognitive Ability in Children. Psychological Science 9 (3) , pp. 159-166. 10.1111/1467-9280.00032

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Abstract

Quantitative trait loci (QTLs) associated with general cognitive ability (g) were investigated for several groups of children selected for very high or for average cognitive functioning. A DNA marker in the gene for insulin-like growth factor-2 receptor (IGF2R) on Chromosome 6 yielded a significantly greater frequency of a particular form of the gene (allele) in a high-g group (.303; average IQ = 136, N = 51) than in a control group (.156, average IQ = 103, N = 51). This association was replicated in an extremely-high-g group (all estimated IQs > 160, N = 52) as compared with an independent control group (average IQ = 101, N = 50), with allelic frequencies of .340 and .169, respectively. Moreover, a high-mathematics-ability group (N = 62) and a high-verbal-ability group (N = 51) yielded results that were in the same direction but only marginally significant (p = .06 and .08, respectively).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Blackwell
ISSN:	09567976
Last Modified:	31 Oct 2022 09:55
URI:	https://orca.cardiff.ac.uk/id/eprint/82911

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