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Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease

Smemo, S1, Nowotny, P., Hinrichs, A. L., Kauwe, J. S., Cherny, S., Erickson, K, Myers, A. J., Kaleem, M., Marlowe, L., Gibson, A. M., Hollingworth, P., O'Donovan, Michael Conlon, Morris, C. M., Holmans, Peter Alan, Lovestone, S., Morris, J. C., Thal, L., Li, Y., Grupe, A., Hardy, J., Owen, Michael John, Williams, J. and Goate, A. 2006. Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease. Annals of Neurology 59 (1) , pp. 21-26. 10.1002/ana.20673

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Several studies have reported evidence for linkage of late-onset Alzheimer's disease (LOAD) to chromosome 9. Recently, an intronic polymorphism affecting alternative splicing of exon 8 of ubiquilin 1 (UBQLN1) was reported to be associated with LOAD. We attempted to replicate this observation by genotyping this polymorphism, rs12344615 (also known as UBQ-8i), in a large sample of 1,544 LOAD cases and 1,642 nondemented controls. We did not find any evidence that this single nucleotide polymorphism, or any of six others tested in UBQLN1, increases risk for LOAD. Williams J, Goate A.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Wiley-Blackwell
ISSN: 0364-5134
Last Modified: 02 May 2019 12:54

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