Glaser, B1, Schumacher, J., Williams, H. J., Jamra, R. A., Ianakiev, N., Milev, R., Ohlraun, S., Schulze, T. G., Czerski, P. M., Hauser, J., Jonsson, E. G., Sedvall, G. C., Klopp, N., Illig, T., Becker, T., Propping, P., Williams, Nigel Melville ![]() ![]() ![]() ![]() |
Abstract
BACKGROUND: It has been recently reported that a functional variant in the ZDHHC8 gene encoding a putative palmitoyltransferase directly confers susceptibility to schizophrenia in females (). METHODS: We investigated the putative risk allele (rs175174) in four schizophrenia association samples including a Bulgarian proband and parent sample (474 trios) and three case-control panels of European origin (1028 patients/1253 control subjects) in an attempt to replicate these findings. RESULTS: Our results do not support the hypothesis that genetic variation at rs175174 is associated with increased risk for schizophrenia nor do they suggest the presence of gender-specific differences. CONCLUSIONS: Our data suggest that the reported genetic association by either represents type I error resulting from sampling variance or that rs175174 is in linkage disequilibrium (LD) with the functional variant for schizophrenia and different LD patterns obscure the detection of association.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII) |
Subjects: | R Medicine > R Medicine (General) |
Publisher: | Elsevier |
ISSN: | 0006-3223 |
Last Modified: | 17 Nov 2022 13:27 |
URI: | https://orca.cardiff.ac.uk/id/eprint/83439 |
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