No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples

Glaser, B1, Schumacher, J., Williams, H. J., Jamra, R. A., Ianakiev, N., Milev, R., Ohlraun, S., Schulze, T. G., Czerski, P. M., Hauser, J., Jonsson, E. G., Sedvall, G. C., Klopp, N., Illig, T., Becker, T., Propping, P., Williams, Nigel Melville ORCID: https://orcid.org/0000-0003-1177-6931, Cichon, S., Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, Rietschel, M., Murphy, K. C., O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379, Nothen, M. M. and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 2005. No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples. Biological psychiatry 58 (1) , pp. 78-80.

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Abstract

BACKGROUND: It has been recently reported that a functional variant in the ZDHHC8 gene encoding a putative palmitoyltransferase directly confers susceptibility to schizophrenia in females (). METHODS: We investigated the putative risk allele (rs175174) in four schizophrenia association samples including a Bulgarian proband and parent sample (474 trios) and three case-control panels of European origin (1028 patients/1253 control subjects) in an attempt to replicate these findings. RESULTS: Our results do not support the hypothesis that genetic variation at rs175174 is associated with increased risk for schizophrenia nor do they suggest the presence of gender-specific differences. CONCLUSIONS: Our data suggest that the reported genetic association by either represents type I error resulting from sampling variance or that rs175174 is in linkage disequilibrium (LD) with the functional variant for schizophrenia and different LD patterns obscure the detection of association.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	0006-3223
Last Modified:	17 Nov 2022 13:27
URI:	https://orca.cardiff.ac.uk/id/eprint/83439

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