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No evidence for association between polymorphisms in GRM3 and schizophrenia

Norton, Nadine, Williams, Hywel, Dwyer, Sarah, Ivanov, Dobril, Preece, Anna, Gerrish, Amy, Williams, Nigel Melville, Yerassimou, P., Zammit, Stanley, O'Donovan, Michael Conlon and Owen, Michael John 2005. No evidence for association between polymorphisms in GRM3 and schizophrenia. BMC Psychiatry 5 , 23. 10.1186/1471-244X-5-23

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BACKGROUND: Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the metabotropic glutamate receptor GRM3. METHODS: In a bid to examine this hypothesis, we examined seven SNPs spanning GRM3 in a UK case-control sample (schizophrenic cases n = 674, controls n = 716). These included all SNPs previously reported to be associated, alone or in haplotypes, with schizophrenia in European or European American samples. RESULTS: Our data showed no evidence for association with single markers, or 2, 3, 4 and 5 marker haplotypes, nor did any specific haplotypes show evidence for association according to previously observed patterns. CONCLUSION: Examination of our own data and those of other groups leads us to conclude that at present, GRM3 should not be viewed as a gene for which there is replicated evidence for association with schizophrenia.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: BioMed Central
ISSN: 1471-244X
Date of First Compliant Deposit: 22 August 2018
Last Modified: 09 Oct 2019 10:15

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