Combining research approaches to advance our understanding of drug addiction

van den Bree, Marianne Bernadette ORCID: https://orcid.org/0000-0002-4426-3254 2005. Combining research approaches to advance our understanding of drug addiction. Current Psychiatry Reports 7 (2) , pp. 125-132. 10.1007/s11920-005-0009-4

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Abstract

Drug addiction is a complex behavior, likely to be influenced by various genes, environmental factors, and gene-gene and gene-environment interactions. Various aspects of addiction are studied by different disciplines. Animal studies are increasing insight into brain regions and genes associated with addiction. Epidemiologic studies are establishing the factors increasing risk for initiation and continuation of substance use. Twin and adoption studies are increasing our understanding of the complex mechanisms involved in substance use, including comorbidity and gene environment interaction. Finally, molecular genetic studies in humans are starting to yield some converging findings. It is argued and illustrated with examples that greater awareness of progress in other disciplines can speed up our understanding of the complex processes involved in addiction. This should help our ability to identify who is at increased risk of becoming addicted and the development of prevention and intervention strategies targeted at an individual's specific needs.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Current Science Inc
ISSN:	1523-3812
Last Modified:	31 Oct 2022 10:04
URI:	https://orca.cardiff.ac.uk/id/eprint/83521

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