HTR2A: association and expression studies in neuropsychiatric genetics

Norton, N. and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 2005. HTR2A: association and expression studies in neuropsychiatric genetics. Annals of Medicine 37 (2) , pp. 121-129.

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Abstract

Over the last decade the gene encoding 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) has been implicated as a functional candidate in many neuropsychiatric phenotypes including: schizophrenia, attention deficit hyperactivity disorder (ADHD), affective disorders, eating disorders, anxiety disorders, obsessive-compulsive disorder, suicide and Alzheimer's disease (AD). Different studies have tested for genetic association (case-control and family-based studies), protein expression (receptor binding assays), transcriptional expression (mRNA assays) and allelic expression. In this review we examine and summarize these findings in various neuropsychiatric phenotypes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Informa Healthcare
ISSN:	0785-3890
Last Modified:	31 Oct 2022 10:05
URI:	https://orca.cardiff.ac.uk/id/eprint/83632

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