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Association of ABCA1 with late-onset Alzheimer?s disease is not observed in a case-control study

Li, Yonghong, Tacey, Kristina, Doil, Lisa, Luchene, Ryan van, Garcia, Veronica, Rowland, Charles, Schrodi, Steve, Leong, Diane, Lau, Kit, Catanese, Joe, Sninsky, John, Nowotny, Petra, Holmans, Peter, Hardy, John, Powell, John, Lovestone, Simon, Thal, Leon, Owen, Michael John, Williams, Julie, Goate, Alison and Grupe, Andrew 2004. Association of ABCA1 with late-onset Alzheimer?s disease is not observed in a case-control study. Neuroscience Letters 366 (3) , pp. 268-271. 10.1016/j.neulet.2004.05.047

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Genetic association of ABCA1 or the ATP-binding cassette A1 transporter with late-onset Alzheimer's disease (LOAD) has recently been proposed for a haplotype comprised of three single nucleotide polymorphisms (SNPs). We have genotyped these and other ABCA1 SNPs in a LOAD case-control series of 796 individuals (419 cases versus 377 controls) collected at Washington University. While our sample series is larger and thus presumably has greater power than any of the series used to implicate ABCA1, we were unable to replicate the published association, using either single markers or multiple marker haplotypes. Further, we did not observe significant and replicated association of other ABCA1 SNPs we examined with the disease, thus these ABCA1 variants do not appear to influence the risk of LOAD in this study.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
ISSN: 0304-3940
Last Modified: 02 May 2019 12:55

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