Prevalence of defined ultrasound findings of unknown significance at the second trimester fetal anomaly scan and their association with adverse pregnancy outcomes: the Welsh study of mothers and babies population-based cohort

Hurt, Lisa ORCID: https://orcid.org/0000-0002-2741-5383, Wright, Melissa ORCID: https://orcid.org/0000-0002-1011-4795, Dunstan, Frank ORCID: https://orcid.org/0000-0002-1043-5281, Thomas, Susan, Brook, Fiona, Morris, Susan, Tucker, David, Wills, Marilyn Ann, Davies, Colin, John, Gareth, Fone, David ORCID: https://orcid.org/0000-0002-6476-4881 and Paranjothy, Shantini ORCID: https://orcid.org/0000-0002-0528-3121 2016. Prevalence of defined ultrasound findings of unknown significance at the second trimester fetal anomaly scan and their association with adverse pregnancy outcomes: the Welsh study of mothers and babies population-based cohort. Prenatal Diagnosis 36 (1) , pp. 40-48. 10.1002/pd.4708

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Abstract

Objective The aim of this article was to estimate the population prevalence of seven defined ultrasound findings of uncertain significance (‘markers’) in the second trimester and the associated risk of adverse pregnancy outcomes. Method A prospective record-linked cohort study of 30 078 pregnant women who had second trimester anomaly scans between July 2008 and March 2011 in Wales was conducted. Results The prevalence of markers ranged from 43.7 per 1000 singleton pregnancies for cardiac echogenic foci [95% confidence interval (CI): 38.8, 51.1] to 0.6 for mild-to-moderate ventriculomegaly (95% CI: 0.3, 1.0). Isolated echogenic bowel was associated with an increased risk of congenital anomalies [risk ratio (RR) 4.54, 95% CI: 2.12, 9.73] and preterm birth (RR 2.30, 95% CI: 1.08, 4.90). Isolated pelvicalyceal dilatation was associated with an increased risk of congenital anomalies (RR 3.82, 95% CI: 2.16, 6.77). Multiple markers were associated with an increased risk of congenital anomalies (RR 5.00, 95% CI: 1.35, 18.40) and preterm birth (RR 3.38, 95% CI 1.20, 9.53). Conclusions These data are useful for counselling families and developing clinical guidance and care pathways following the detection of markers in clinical practice, particularly the need for follow-up scans to monitor placental function and growth in pregnancies with isolated echogenic bowel, and further investigation for multiple markers

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RA Public aspects of medicine R Medicine > RG Gynecology and obstetrics
Additional Information:	Article first published online: 20 NOV 2015 This is an open access article under the terms of the Creative Commons Attribution License
Publisher:	Wiley
ISSN:	0197-3851
Funders:	Medical Research Council
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	6 October 2015
Last Modified:	17 Jan 2024 07:22
URI:	https://orca.cardiff.ac.uk/id/eprint/84157

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