Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study

Daughters, Katie ORCID: https://orcid.org/0000-0001-5889-8464, Manstead, Antony Stephen Reid ORCID: https://orcid.org/0000-0001-7540-2096, Hubble, Kelly ORCID: https://orcid.org/0000-0002-9280-6268, Rees, Dafydd Aled ORCID: https://orcid.org/0000-0002-1165-9092, Thapar, Anita ORCID: https://orcid.org/0000-0002-3689-737X and Van Goozen, Stephanie Helena Maria ORCID: https://orcid.org/0000-0002-5983-4734 2015. Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study. PLoS ONE 10 (12) , e0145104. 10.1371/journal.pone.0145104

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Abstract

The use of intranasal oxytocin (OT) in research has become increasingly important over the past decade. Although researchers have acknowledged a need for further investigation of the physiological effects of intranasal administration, few studies have actually done so. In the present double-blind cross-over study we investigated the longevity of a single 24 IU dose of intranasal OT measured in saliva in 40 healthy adult males. Salivary OT concentrations were significantly higher in the OT condition, compared to placebo. This significant difference lasted until the end of testing, approximately 108 minutes after administration, and peaked at 30 minutes. Results showed significant individual differences in response to intranasal OT administration. To our knowledge this is the largest and first all-male within-subjects design study to demonstrate the impact of intranasal OT on salivary OT concentrations. The results are consistent with previous research in suggesting that salivary OT is a valid matrix for OT measurement. The results also suggest that the post-administration ‘wait-time’ prior to starting experimental tasks could be reduced to 30 minutes, from the 45 minutes typically used, thereby enabling testing during peak OT concentrations. Further research is needed to ascertain whether OT concentrations after intranasal administration follow similar patterns in females, and different age groups.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Psychology Neuroscience and Mental Health Research Institute (NMHRI) MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > R Medicine (General)
Additional Information:	© 2015 Daughters et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Publisher:	Public Library of Science
ISSN:	1932-6203
Funders:	ESRC
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	26 November 2015
Last Modified:	07 May 2023 09:18
URI:	https://orca.cardiff.ac.uk/id/eprint/84312

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