X-ray scattering used to map the preferred collagen orientation in the human cornea and limbus

Aghamohammadzadeh, Hossein, Newton, Richard Hugh and Meek, Keith Michael Andrew ORCID: https://orcid.org/0000-0002-9948-7538 2004. X-ray scattering used to map the preferred collagen orientation in the human cornea and limbus. Structure 12 (2) , pp. 249-256. 10.1016/S0969-2126(04)00004-8

Full text not available from this repository.

Abstract

Many properties of connective tissues are governed by the organization of the constituent collagen. For example, the organization of collagen in the cornea and the limbus, where the cornea and sclera meet, is an important determinant of corneal curvature and hence of the eye's focusing power. We have used synchrotron X-ray scattering to map the orientation of the collagen fibrils throughout the human cornea, limbus, and adjacent sclera. We demonstrate a preferred orientation of collagen in the vertical and horizontal directions that is maintained to within about 1 mm from the limbus, where a circular or tangential disposition of fibrils occurs. The data are also used to map the relative distribution of both the total and the preferentially aligned collagen in different parts of the tissue, revealing considerable anisotropy. The detailed structural information provided is an important step toward understanding the shape and the mechanical properties of the tissue.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences
ISSN:	15459985
Last Modified:	17 Oct 2022 08:42
URI:	https://orca.cardiff.ac.uk/id/eprint/844

Citation Data

Cited 199 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item