The role of death-associated protein 3 in apoptosis, anoikis and human cancer

Wazir, Umar, Orakzai, Mona M.A.W., Khanzada, Zubair S., Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111, Sharma, Anup K., Kasem, Abdul and Mokbel, Kefah 2015. The role of death-associated protein 3 in apoptosis, anoikis and human cancer. Cancer Cell International 15 , 39. 10.1186/s12935-015-0187-z

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Abstract

Death-associated protein 3 (DAP3) is a molecule with a significant role in the control of both apoptosis and anoikis. Apoptosis is the predominant type of programmed cell death (PCD) which may occur in response to irreparable damage to DNA, or in response to induction by inflammatory cells. Anoikis is subset of apoptosis which occurs in epithelial cells in response to detachment from the surrounding matrix. Both apoptosis and anoikis are of interest in the context of carcinogenesis. In this review, we shall discuss apoptosis and anoikis, and the recent literature regarding the role of DAP3 in both these pathways.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	Apoptosis Review Death-associated protein 3 Anoikis Cancer Carcinogenesis Oncogenesis Breast cancer
Publisher:	BioMed Central
ISSN:	1475-2867
Funders:	Breast Cancer Hope Foundation
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	18 March 2015
Last Modified:	09 Jul 2023 16:33
URI:	https://orca.cardiff.ac.uk/id/eprint/84505

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