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Mechanisms of disease: nicotine - a review of its actions in the context of gastrointestinal disease

Thomas, G. A. O., Rhodes, J. and Ingram, John R. 2005. Mechanisms of disease: nicotine - a review of its actions in the context of gastrointestinal disease. Nature Clinical Practice Gastroenterology & Hepatology 2 (11) , pp. 536-544. 10.1038/ncpgasthep0316

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Smoking tobacco is associated with a number of gastrointestinal disorders. In some, such as Crohn's disease and peptic ulcer disease, it increases the risk of disease and has a detrimental effect on their course. In others, such as ulcerative colitis, it decreases the risk of disease and can have a favorable effect on disease course and severity. In the eighteenth and nineteenth centuries, nicotine was used as a 'panacea' for various ailments, including abdominal symptoms--it is now under investigation to elucidate its role in gastrointestinal diseases that are associated with smoking. The actions of nicotine are complex; it is likely that its effects on the central nervous system, gastrointestinal tract and immune system interact with other risk factors, such as genetic susceptibility, to influence disease outcomes. This review focuses on the mechanisms of action of nicotine that might be relevant in gastrointestinal disease.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Uncontrolled Keywords: gastrointestinal disease, gastrointestinal tract, mechanisms, nicotine, smoking
Publisher: Nature Publishing Group
Date of Acceptance: 12 September 2005
Last Modified: 04 Jun 2017 08:47

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