Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings

Zhou, Kaixin, Asherson, Philip, Sham, Pak, Franke, Barbara, Anney, Richard ORCID: https://orcid.org/0000-0002-6083-407X, Buitelaar, Jan, Ebstein, Richard, Gill, Michael, Brookes, Keeley, Buschgens, Cathelijne, Campbell, Desmond, Chen, Wai, Christiansen, Hanna, Fliers, Ellen, Gabris, Isabel, Johansson, Lena, Marco, Rafaela, Mulas, Fernando, Mueller, Ueli, Mulligan, Aisling, Neale, Benjamin M., Rijsdijk, Fruhling, Rommelse, Nanda, Uebel, Henrik, Psychogiou, Lamprini, Xu, Xiaohui, Banaschewski, Tobias, Sonuga-Barke, Edmund J. S., Eisenberg, Jacques, Manor, Iris, Miranda, Ana, Oades, Robert D., Roeyers, Herbert, Rothenberger, Aribert, Sergeant, Joseph, Steinhausen, Hans-Christoph, Taylor, Eric, Thompson, Margaret and Faraone, Stephen V. 2008. Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings. Biological psychiatry 64 (7) , pp. 571-576. 10.1016/j.biopsych.2008.02.024

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Abstract

Background Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). Methods A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. Results A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p < .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait. Conclusions These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	ADHD; linkage; QTL
Publisher:	Elsevier
ISSN:	0006-3223
Last Modified:	31 Oct 2022 10:32
URI:	https://orca.cardiff.ac.uk/id/eprint/85267

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