DC-T cell virological synapses and the skin: novel perspectives in dermatology

Shimauchi, Takatoshi and Piguet, Vincent 2015. DC-T cell virological synapses and the skin: novel perspectives in dermatology. Experimental Dermatology 24 (1) , pp. 1-4. 10.1111/exd.12511

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Abstract

Virological synapses (VS) increase cell-to-cell viral transmission and facilitate propagation of human immunodeficiency virus type 1 (HIV-1) and human T-cell leukaemia virus type 1 (HTLV-1). VS formation also plays a more general role in viral replication and dissemination. VS have been observed in vitro and ex vivo between uninfected T cells and T cells infected with HIV-1 or HTLV-1. In addition, dendritic cells (DC) infected with HIV-1 also play an important role in viral transmission to uninfected CD4+ T cells via VS formation. Recent studies revealed that several DC subsets are also infected with HTLV-1. These findings may help explain the rapid dissemination of both viruses within secondary lymphoid tissues in vivo. VS also explain, at least in part, why HIV-1 can propagate in the mucosal sites during sexual transmission. Furthermore, in the case of HTLV-1, VS can potentially explain some of the features of HTLV-1-associated dermatitis as infected T cells in the skin contribute to the pathogenesis of this condition.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	DC-SIGN;dendritic cell;HIV-1;HTLV-1;virological synapse
Publisher:	Wiley-Blackwell
ISSN:	0906-6705
Date of Acceptance:	16 July 2014
Last Modified:	13 Jun 2019 09:40
URI:	https://orca.cardiff.ac.uk/id/eprint/85804

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