Alzheimer's disease: the amyloid hypothesis on trial

Harrison, Judith ORCID: https://orcid.org/0000-0002-5775-2524 and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 2016. Alzheimer's disease: the amyloid hypothesis on trial. British Journal of Psychiatry 208 (1) , pp. 1-3. 10.1192/bjp.bp.115.167569

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Abstract

The pathogenesis of Alzheimer's disease is complex. The amyloid hypothesis has directed research efforts for many years, but it has recently been questioned after failed drug trials. Here, we review the evidence for and against and suggest that it might be premature to abandon the amyloid hypothesis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Royal College of Psychiatrists
ISSN:	0007-1250
Date of First Compliant Deposit:	10 October 2018
Date of Acceptance:	21 July 2015
Last Modified:	12 Nov 2023 17:09
URI:	https://orca.cardiff.ac.uk/id/eprint/87545

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