Interleukin-24 (IL-24) expression and biological impact on HECV endothelial cells.

Tan, Y., Sanders, Andrew J. ORCID: https://orcid.org/0000-0002-7997-5286, Xie, Y., Martin, Tracey Amanda ORCID: https://orcid.org/0000-0003-2690-4908, Owen, Sioned, Ruge, Fiona and Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 2015. Interleukin-24 (IL-24) expression and biological impact on HECV endothelial cells. Cancer Genomics and Proteomics 12 (5) , pp. 243-250.

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Abstract

Background: IL-24, also termed MDA-7, is a member of the IL-10 family of cytokines. IL-24 is reported to be expressed in a series of cell lines, including keratinocytes as well as breast, lung and prostate cancer cells, but was primarily found in a human melanoma cell line. IL-24 is suggested to have many biological properties displaying anti-tumour effects via induction of apoptosis, suppressing proliferation, invasion and metastasis of cancer cells. IL-24 has also been reported to inhibit the migration of cancer cells and keratinocytes, and have anti-angiogeneic properties. The biological functions of IL-24 are regulated through both autocrine and paracrine methods. However, currently there exists little knowledge regarding the effect of IL-24 on endothelial cell biology. Materials and Methods: The impact of rhIL-24 on human endothelial HECV cell growth, migration, trans-endothelial resistance and angiogenic potential was examined using cellular functional assays. Additionally, the relationship between IL-24 and a number of cell junction proteins were examined using immunofluorescence staining. Results: IL-24 and receptor molecules was found to be expressed in HECV endothelial cells. Treatment of this cell line with rhIL-24 was found to promote cell migration rates and suppress tubule formation. Conclusion: Treatment of HECV cells with rhIL-24 can promote migration and inhibit tubule formation but does not impact cell growth or permeability at the tested concentrations. Potential links between IL-24 and AKT or PLCγ-related pathways with regard to these effects are also presented in the present study.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher:	International Institute of Anticancer Research
ISSN:	1109-6535
Last Modified:	01 Nov 2022 09:29
URI:	https://orca.cardiff.ac.uk/id/eprint/88110

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