Expression of semaphorin 3C in breast cancer and its impact on adhesion and invasion of breast cancer cells

Malik, M. F. A., Satherley, Lucy, Davies, Eleri-Lloyd, Ye, Lin ORCID: https://orcid.org/0000-0002-0303-2409 and Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 2016. Expression of semaphorin 3C in breast cancer and its impact on adhesion and invasion of breast cancer cells. Anticancer Research 36 (3) , pp. 1281-1286.

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Abstract

ackground: The aim of the current study was to examine the role of semaphorin 3C (SEMA3C) in breast cancer. Materials and Methods: SEMA3C transcripts expressed by breast tissues were determined using real-time polymerase chain reaction (PCR). Knock-down of SEMA3C was performed in MDA-MB-231 and MCF-7 breast cancer cell lines using anti-SEMA3C hammerhead ribozyme transgenes. The effect of SEMA3C knockdown on cancer cells was determined using in vitro cellular function assays. Results: Higher SEMA3C transcript levels were significantly associated with poor differentiation of cancer cells, and transcript levels were significantly reduced in oestrogen receptor-positive tumours. Knock-down of SEMA3C expression resulted in a decrease in cell proliferation, adhesion and invasion of breast cancer cells. Conclusion: Higher SEMA3C expression is correlated with tumour differentiation. Inhibition of SEMA3C reduces adhesion and invasion of breast cancer cells. This suggests that SEMA3C may play a significant role in morphological changes of cancer cells, leading to enhanced growth and dissemination.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > RC Internal medicine
Publisher:	International Institute of Anticancer Research
ISSN:	0250-7005
Funders:	Cardiff China Medical Scholarship and Cancer Research Wales
Date of First Compliant Deposit:	11 April 2016
Date of Acceptance:	14 February 2016
Last Modified:	01 Nov 2022 09:44
URI:	https://orca.cardiff.ac.uk/id/eprint/89058

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