The imprinted Phlda2 gene regulates extraembryonic energy stores

Tunster, Simon James ORCID: https://orcid.org/0000-0002-2242-9452, Tycko, B and John, Rosalind Margaret ORCID: https://orcid.org/0000-0002-3827-7617 2010. The imprinted Phlda2 gene regulates extraembryonic energy stores. Molecular and Cellular Biology 30 (1) , pp. 295-306. 10.1128/MCB.00662-09

Preview

PDF - Published Version Download (5MB) | Preview

Abstract

An important difference between placental mammals and marsupials is the maturity of the fetus at birth. Placental mammals achieved this maturity by developing a complex and invasive placenta to support and prolong internal development. The exact genomic modifications that facilitated the evolution of this complex structure are unknown, but the emergence of genomic imprinting within mammalian lineages suggests a role for gene dosage. Here we show that a maximally altered placental structure is achieved by a single extra dose of the imprinted Phlda2 gene characterized by a dramatically reduced junctional zone and a decrease in stored glycogen. In addition, glycogen cells do not migrate into the maternal decidua in a timely fashion, but instead, Tpbpa-positive cells progressively mislocalize into the labyrinth. These defects are linked to a progressive restriction of embryonic growth from embryonic day 16.5. This work has identified a critical role for the imprinted Phlda2 gene in regulating glycogen storage in the eutherian placenta and implies that imprinting has provided a mechanism to boost nutrient supply to the fetus late in gestation, when the fetus is placing the highest demands on maternal resources, to enhance growth.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Additional Information:	Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/0270-7306/ (accessed 25/02/2014)
Publisher:	American Society for Microbiology
ISSN:	0270-7306
Date of First Compliant Deposit:	30 March 2016
Last Modified:	14 May 2023 20:15
URI:	https://orca.cardiff.ac.uk/id/eprint/8978

Citation Data

Cited 99 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item