Laminar analysis of the role of GluR1 in experience-dependent and synaptic depression in barrel cortex

Wright, Nicholas Fraser, Glazewski, Stanislaw, Hardingham, Neil Robert, Phillips, Keith, Pervolaraki, Eleftheria ORCID: https://orcid.org/0000-0002-2842-7562 and Fox, Kevin Dyson ORCID: https://orcid.org/0000-0002-2563-112X 2008. Laminar analysis of the role of GluR1 in experience-dependent and synaptic depression in barrel cortex. Nature Neuroscience 11 (10) , pp. 1140-1142. 10.1038/nn.2188

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Abstract

Several synaptic depression mechanisms have been described for the hippocampus, cerebellum and neocortex in vitro, but little is known about which, if any, are engaged during experience-dependent depression (EDD). We found that EDD in the mouse barrel cortex depends on the AMPA subunit GluR1 in layers II/III and IV, but not in layer V, and that long-term depression is also GluR1 dependent in the IV-II/III, but not II/III–V, pathway.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences Schools > Psychology
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Nature Publishing Group
ISSN:	1097-6256
Last Modified:	02 Dec 2022 11:54
URI:	https://orca.cardiff.ac.uk/id/eprint/8989

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