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Sol-gel synthesis of quaternary (P2O5)(55)-(CaO)(25)-(Na2O)((20-x))-(TiO2)(x) bioresorbable glasses for bone tissue engineering applications (x=0, 5, 10, or 15)

Foroutan, Farzad, Walters, Nick J., Owens, Gareth J., Mordan, Nicola J., Kim, Hae-Won, de Leeuw, Nora and Knowles, Jonathan C. 2015. Sol-gel synthesis of quaternary (P2O5)(55)-(CaO)(25)-(Na2O)((20-x))-(TiO2)(x) bioresorbable glasses for bone tissue engineering applications (x=0, 5, 10, or 15). Biomedical Materials 10 (4) , 045025.

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In the present study, we report a new and facile sol–gel synthesis of phosphate-based glasses with the general formula of (P2O5)55–(CaO)25–(Na2O)(20−x)–(TiO2) x , where x = 0, 5, 10 or 15, for bone tissue engineering applications. The sol–gel synthesis method allows greater control over glass morphology at relatively low processing temperature (200 °C) in comparison with phosphate-based melt-derived glasses (~1000 °C). The glasses were analyzed using several characterization techniques, including x-ray diffraction (XRD), 31P magic angle spinning nuclear magnetic resonance (31P MAS-NMR), Fourier transform infrared (FTIR) spectroscopy and energy-dispersive x-ray (EDX) spectroscopy, which confirmed the amorphous and glassy nature of the prepared samples. Degradation was assessed by measuring the ion release and pH change of the storage medium. Cytocompatibility was also confirmed by culturing osteoblast-like osteosarcoma cell line MG-63 on the glass microparticles over a seven-day period. Cell attachment to the particles was imaged using scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). The results revealed the potential of phosphate-based sol–gel derived glasses containing 5 or 10 mol% TiO2, with high surface area, ideal dissolution rate for cell attachment and easily metabolized dissolution products, for bone tissue engineering applications.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: IOP Science
ISSN: 1748-6041
Date of First Compliant Deposit: 27 April 2016
Last Modified: 04 Jun 2017 09:04

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