Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation

Celiz, Adam D., Smith, James G. W., Patel, Asha K., Hook, Andrew L., Rajamohan, Divya, George, Vinoj T., Flatt, Luke, Patel, Minal J., Epa, Vidana C., Singh, Taranjit, Langer, Robert, Anderson, Daniel G., Allen, Nicholas Denby ORCID: https://orcid.org/0000-0003-4009-186X, Hay, David C., Winkler, David A., Barrett, David A., Davies, Martyn C., Young, Lorraine E., Denning, Chris and Alexander, Morgan R. 2015. Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation. Advanced Materials 27 (27) , pp. 4006-4012. 10.1002/adma.201501351

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Abstract

A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after long-term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC-derived cells to be realized.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > QH Natural history > QH426 Genetics
Publisher:	Wiley-VCH
ISSN:	0935-9648
Last Modified:	01 Nov 2022 10:14
URI:	https://orca.cardiff.ac.uk/id/eprint/90789

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