Management of prematurity-associated wheeze and its association with atopy

Edwards, Martin, Kotecha, Sarah Joanne, Lowe, John ORCID: https://orcid.org/0000-0003-4772-1879, Richards, Louise, Watkins, William John ORCID: https://orcid.org/0000-0003-3262-6588 and Kotecha, Sailesh ORCID: https://orcid.org/0000-0003-3535-7627 2016. Management of prematurity-associated wheeze and its association with atopy. PLoS ONE 11 (5) , e0155695. 10.1371/journal.pone.0155695

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Abstract

Introduction Although preterm birth is associated with respiratory morbidity in childhood, the role of family history of atopy and whether appropriate treatment has been instituted is unclear. Thus we assessed (i) the prevalence of respiratory symptoms, particularly wheezing, in childhood; (ii) evaluated the role of family history of atopy and mode of delivery, and (iii) documented the drug usage, all in preterm-born children compared to term-born control children. Methods We conducted a cross-sectional population-based questionnaire study of 1–10 year-old preterm-born children (n = 13,361) and matched term-born controls (13,361). Data (n = 7,149) was analysed by gestational groups (24–32 weeks, 33–34 weeks, 35–36 weeks and 37–43 weeks) and by age, <5 years old or ≥ 5 years. Main Results Preterm born children aged <5 years (n = 2,111, term n = 1,402) had higher rates of wheeze-ever [odds ratio: 2.7 (95% confidence intervals 2.2, 3.3); 1.8 (1.5, 2.2); 1.5 (1.3, 1.8) respectively for the 24–32 weeks, 33–34 weeks, 35–36 weeks groups compared to term]. Similarly for the ≥5 year age group (n = 2,083, term n = 1,456) wheezing increased with increasing prematurity [odds ratios 3.3 (2.7, 4.1), 1.8 (1.5, 2.3) and 1.6 (1.3, 1.9) for the three preterm groups compared to term]. At both age groups, inhaler usage was greater in the lowest preterm group but prematurity-associated wheeze was independent of a family history of atopy. Conclusions Increasing prematurity was associated with increased respiratory symptoms, which were independent of a family history of atopy. Use of bronchodilators was also increased in the preterm groups but its efficacy needs careful evaluation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Public Library of Science
ISSN:	1932-6203
Funders:	Medical Research Council
Date of First Compliant Deposit:	24 May 2016
Date of Acceptance:	17 May 2016
Last Modified:	10 Nov 2023 02:11
URI:	https://orca.cardiff.ac.uk/id/eprint/91210

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