Comparable reduction in Zif268 levels and cytochrome oxidase activity in the retrosplenial cortex following mammillothalamic tract lesions

Frizzati, Aura ORCID: https://orcid.org/0000-0002-7002-6180, Milczarek, Michal M., Sengpiel, Frank ORCID: https://orcid.org/0000-0002-7060-1851, Thomas, Kerrie L. ORCID: https://orcid.org/0000-0003-3355-9583, Dillingham, Christopher M. and Vann, Seralynne D. ORCID: https://orcid.org/0000-0002-6709-8773 2016. Comparable reduction in Zif268 levels and cytochrome oxidase activity in the retrosplenial cortex following mammillothalamic tract lesions. Neuroscience 330 , pp. 39-49. 10.1016/j.neuroscience.2016.05.030

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Abstract

Damage to the mammillothalamic tract (MTT) pro- duces memory impairments in both humans and rats, yet it is still not clear why this diencephalic pathway is vital for memory. One suggestion is that it is an important route for midbrain inputs to reach a wider cortical and subcortical net- work that supports memory. Consistent with this idea, MTT lesions produce widespread hypoactivity in distal brain regions as measured by the immediate-early gene, c-fos. To determine whether these findings were selective to c-fos or reflected more general changes in neuronal function, we assessed the effects of MTT lesions on the expression of the immediate-early gene protein, Zif268 and the metabolic marker, cytochrome oxidase, in the retrosplenial cortex and hippocampus. The lesions decreased levels of both activity markers in the superficial and deep layers of the retrosplenial cortex in both its granular and dysgranular subregions. In contrast, no significant changes were observed in the hip- pocampus, despite the MTT-lesioned animals showing marked impairments on T-maze alternation. These findings are consistent with MTT lesions providing important, indirect inputs for normal retrosplenial cortex functioning. These dis- tal functional changes may contribute to the memory impair- ments observed after MTT lesions.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Psychology Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology Q Science > Q Science (General) R Medicine > R Medicine (General)
Additional Information:	This is an open access article under the terms of the CC-BY license.
Publisher:	Elsevier
ISSN:	0306-4522
Funders:	Wellcome Trust
Date of First Compliant Deposit:	30 June 2016
Date of Acceptance:	16 May 2016
Last Modified:	07 Nov 2023 11:19
URI:	https://orca.cardiff.ac.uk/id/eprint/92213

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