Matrix-bound fibroblasts regulate angiogenesis by modulation of VE-cadherin

Martin, Tracey Amanda ORCID: https://orcid.org/0000-0003-2690-4908, Harding, Keith Gordon and Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 2001. Matrix-bound fibroblasts regulate angiogenesis by modulation of VE-cadherin. European Journal of Clinical Investigation 31 (11) , pp. 931-938. 10.1046/j.1365-2362.2001.00914.x

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Abstract

Background Vascular endothelial cadherin (VE-cadherin/cadherin-5) has previously been described as playing a specific role in angiogenesis due to its localisation at areas of intercellular contact, where it functions in maintenance of tubular architecture. Matrix-bound fibroblasts have been show to produce a number of factors that are important in inducing angiogenesis and to promote tubule-formation by human endothelial cells, an indicator of angiogenic potential. Results Tubule formation stimulated by fibroblast-derived growth factors can be prevented by the addition of monoclonal antibody to VE-cadherin. In addition, fibroblasts-derived growth factors are able to modulate the expression and hence the regulation of this endothelial cell specific cadherin. Conclusions The change in VE-cadherin expression of human endothelial cells by fibroblast-derived growth factors may contribute to the regulation of angiogenesis.

Item Type:	Article
Status:	Published
Schools:	Medicine
Publisher:	Wiley-Blackwell
ISSN:	0014-2972
Last Modified:	19 Nov 2022 08:39
URI:	https://orca.cardiff.ac.uk/id/eprint/92481

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