Martin, Tracey Amanda ![]() ![]() |
Abstract
Background Vascular endothelial cadherin (VE-cadherin/cadherin-5) has previously been described as playing a specific role in angiogenesis due to its localisation at areas of intercellular contact, where it functions in maintenance of tubular architecture. Matrix-bound fibroblasts have been show to produce a number of factors that are important in inducing angiogenesis and to promote tubule-formation by human endothelial cells, an indicator of angiogenic potential. Results Tubule formation stimulated by fibroblast-derived growth factors can be prevented by the addition of monoclonal antibody to VE-cadherin. In addition, fibroblasts-derived growth factors are able to modulate the expression and hence the regulation of this endothelial cell specific cadherin. Conclusions The change in VE-cadherin expression of human endothelial cells by fibroblast-derived growth factors may contribute to the regulation of angiogenesis.
Item Type: | Article |
---|---|
Status: | Published |
Schools: | Medicine |
Publisher: | Wiley-Blackwell |
ISSN: | 0014-2972 |
Last Modified: | 19 Nov 2022 08:39 |
URI: | https://orca.cardiff.ac.uk/id/eprint/92481 |
Citation Data
Cited 24 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
![]() |
Edit Item |