Preventing fractures among older people living in institutional care: a pragmatic randomised double blind placebo controlled trial of vitamin D supplementation

Lyons, R. A., Johansen, A., Brophy, S., Newcombe, Robert G. ORCID: https://orcid.org/0000-0003-4400-8867, Phillips, C. J., Lervy, B., Evans, R., Wareham, K. and Stone, Michael D. 2007. Preventing fractures among older people living in institutional care: a pragmatic randomised double blind placebo controlled trial of vitamin D supplementation. Osteoporosis International 18 (6) , pp. 811-818. 10.1007/s00198-006-0309-5

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Abstract

Introduction Osteoporotic fractures in older people are a major and increasing public health problem. We examined the effect of vitamin D supplementation on fracture rate in people living in sheltered accommodation. Methods In a pragmatic double blind randomised controlled trial of 3 years duration, we examined 3,440 people (2,624 women and 816 men) living in residential or care home. We used four-monthly oral supplementation using 100,000 IU vitamin D2 (ergocalciferol). As a main outcome measure, we used the incidence of first fracture using an intention to treat analysis. This was a multicentre study in 314 care homes or sheltered accommodation complexes in South Wales, UK. Results The vitamin D and placebo groups had similar baseline characteristics. In intention-to-treat analysis, 205 first fractures occurred in the intervention group during a total of 2,846 person years of follow-up (7 fractures per 100 people per year of follow-up), with 218 first fractures in the control group over 2,860 person years of follow-up. The hazard ratio of 0.95 (95% confidence interval 0.79–1.15) for intervention compared to control was not statistically significant. Conclusion Supplementation with four-monthly 100,000 IU of oral vitamin D2 is not sufficient to affect fracture incidence among older people living in institutional care.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Fracture, Institutional care, Prevention, Randomised controlled trial, Vitamin D
ISSN:	0937-941X
Date of Acceptance:	1 December 2006
Last Modified:	01 Nov 2022 10:56
URI:	https://orca.cardiff.ac.uk/id/eprint/93294

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