Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Association of inflammation with specific symptoms of depression in a general population of older people: The English Longitudinal Study of Ageing

White, James, Kivimäki, Mika, Jokela, Markus and Batty, G. David 2017. Association of inflammation with specific symptoms of depression in a general population of older people: The English Longitudinal Study of Ageing. Brain, Behavior, and Immunity 61 , pp. 27-30. 10.1016/j.bbi.2016.08.012

[img]
Preview
PDF - Accepted Post-Print Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (373kB) | Preview

Abstract

Elevated levels of inflammatory markers, such as C-reactive protein, are well documented in people with depression. Few studies have examined whether the association between inflammation and depression is symptom specific, and differs according to antidepressant treatment. Using data from the English Longitudinal Study of Ageing (N = 5 909), cross-sectional analyses revealed a significant dose-response association between C-reactive protein and the symptoms of fatigue (P < 0.001), restless sleep (P = 0.03), low energy (P = 0.02) and feeling depressed (P = 0.04), but not other symptoms. These associations were absent in users of anti-depressant medication. Our findings suggest the C-reactive protein-depression association is symptom-specific and modified by antidepressant treatment.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Uncontrolled Keywords: C-reactive protein; Depression; Antidepressants
Publisher: Elsevier
ISSN: 0889-1591
Date of First Compliant Deposit: 31 August 2016
Date of Acceptance: 21 August 2016
Last Modified: 20 Jan 2021 03:33
URI: http://orca.cardiff.ac.uk/id/eprint/94083

Citation Data

Cited 39 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics