Low-energy electron microscope study of tobacco mosaic viruses

Pereiro Viterbo, Juan ORCID: https://orcid.org/0000-0002-2582-3498, Sadowski, J.T, Lin, B., Panagopoulos, C. and Bozovic, I. 2012. Low-energy electron microscope study of tobacco mosaic viruses. Journal of Nanoscience Letters 2 , p. 29.

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Abstract

Virus microscopy – or perhaps more proper, ‘nanoscopy’, since their typical dimensions are on the nanometer scale – is crucially important for their identification and study. The required high spatial resolution can be achieved by transmission electron microscopy (TEM), but at the expense of using high-energy (typically 50 - 400 keV) electrons that cause substantial radiation damage. A less invasive variant of virus electron microscopy would be highly desirable. Here, we present the first low-energy electron microscope (LEEM) observation of viruses. SrRuO3 films and Nb-doped SrTiO3 bulk single crystals are introduced as excellent new substrates for LEEM studies. High-quality images of the tobacco mosaic virus (TMV) are obtained with electrons at just a few eV, or even without reaching the surface. LEEM offers easy sample preparation, tens of high-resolution images per second, and no radiation damage. With additional capabilities such as spectroscopy and diffraction, it is a promising technique for the study of viruses and other biological nano-objects.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Physics and Astronomy
Subjects:	Q Science > QC Physics
Uncontrolled Keywords:	Microscopy; LEEM; Virus; Oxides; Sputtering
Publisher:	Simplex Academic Publishers
ISSN:	2231-4008
Last Modified:	01 Nov 2022 11:13
URI:	https://orca.cardiff.ac.uk/id/eprint/94220

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