The implications of the shared genetics of psychiatric disorders

O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 2016. The implications of the shared genetics of psychiatric disorders. Nature Medicine 22 , pp. 1214-1219. 10.1038/nm.4196

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Abstract

Recent genomic studies have revealed the highly polygenic nature of psychiatric disorders, including schizophrenia, bipolar disorder and major depressive disorder. Many of the individual genetic associations are shared across multiple disorders in a way that points to extensive biological pleiotropy and further challenges the biological validity of existing diagnostic approaches. Here we argue that the existence of risk alleles specific to a single diagnostic category is unlikely. We also highlight some of the important clinical repercussions of pleiotropy

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Autism spectrum disorders Disease genetics Psychiatric disorders
Publisher:	Nature Publishing Group
ISSN:	1078-8956
Date of First Compliant Deposit:	26 September 2016
Date of Acceptance:	8 September 2016
Last Modified:	30 Nov 2024 13:00
URI:	https://orca.cardiff.ac.uk/id/eprint/94486

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