Aerobic oxidations in flow: opportunities for the fine chemicals and pharmaceuticals industries

Gavriilidis, Asterios, Constantinou, Achilleas, Hellgardt, Klaus, Hii, King Kuok (Mimi), Hutchings, Graham ORCID: https://orcid.org/0000-0001-8885-1560, Brett, Gemma, Kuhn, Simon and Marsden, Stephen P. 2016. Aerobic oxidations in flow: opportunities for the fine chemicals and pharmaceuticals industries. Reaction Chemistry and Engineering 1 (6) , pp. 595-612. 10.1039/C6RE00155F

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Abstract

Molecular oxygen is without doubt the greenest oxidant for redox reactions, yet aerobic oxidation is one of the most challenging to perform with good chemoselectivity, particularly on an industrial scale. This collaborative review (between teams of chemists and chemical engineers) describes the current scientific and operational hurdles that prevent the utilisation of aerobic oxidation reactions for the production of speciality chemicals and active pharmaceutical ingredients (APIs). The safety aspects of these reactions are discussed, followed by an overview of (continuous flow) reactors suitable for aerobic oxidation reactions that can be applied on scale. Some examples of how these reactions are currently performed in the industrial laboratory (in batch and in flow) are presented, with particular focus on the scale-up strategy. Last but not least, further challenges and future perspectives are presented in the concluding remarks.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff Catalysis Institute (CCI) Chemistry
Publisher:	Royal Society of Chemistry
ISSN:	2058-9883
Funders:	EPSRC
Date of First Compliant Deposit:	3 October 2016
Date of Acceptance:	13 September 2016
Last Modified:	06 May 2023 23:01
URI:	https://orca.cardiff.ac.uk/id/eprint/95044

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