Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

HPV-related oropharynx cancer in the United Kingdom: An evolution in the understanding of disease etiology

Schache, A. G., Powell, Ned George, Cuschieri, K. S., Robinson, M., Leary, S., Mehanna, H., Rapozo, D., Long, A., Cubie, H., Junor, E., Monaghan, H., Harrington, K. J., Nutting, C. M., Schick, U., Lau, A. S., Upile, N., Sheard, J., Brougham, K., West, C. M. L., Oguejiofor, K., Thomas, S., Ness, A. R., Pring, M., Thomas, G. J., King, E. V., McCance, D. J., James, J. A., Moran, M., Sloan, P., Shaw, R. J., Evans, M. and Jones, T. M. 2016. HPV-related oropharynx cancer in the United Kingdom: An evolution in the understanding of disease etiology. Cancer Research 76 (22) , pp. 6598-6606. 10.1158/0008-5472.CAN-16-0633

Full text not available from this repository.


A rising incidence of oropharyngeal squamous cell carcinoma (OPSCC) incidence has occurred throughout the developed world, where it has been attributed to an increasing impact of human papillomavirus (HPV) on disease etiology. This report presents the findings of a multicenter cross-sectional retrospective study aimed at determining the proportion of HPV-positive and HPV-negative OPSCC within the United Kingdom. Archival tumor tissue blocks from 1,602 patients previously diagnosed with OPSCC (2002–2011) were collated from 11 centers. HPV status was determined with three validated commercial tests to provide valid data for 1,474 cases in total. Corresponding national incidence data from the same decade were obtained from UK Cancer registries. The overall proportion of HPVþ OPSCC between 2002 and 2011 was 51.8% [95% confidence interval (CI), 49.3–54.4], and this remained unchanged throughout the decade [unadjusted RR ¼ 1.00 (95% CI, 0.99–1.02)]. However, over the same period, the incidence of OPSCC in the broader UK population underwent a 2-fold increase [age-standardized rate 2002: 2.1 (95% CI, 1.9–2.2); 2011: 4.1 (95% CI, 4.0–4.3)]. Although the number of OPSCCs diagnosed within the United Kingdom from 2002 to 2011 nearly doubled, the proportion of HPVþ cases remained static at approximately 50%. Our results argue that the rapidly increasing incidence of OPSCC in the United Kingdom cannot be solely attributable to the influence of HPV. The parallel increase in HPVþ and HPV� cases we documented warrants further investigation, so that appropriate future prevention strategies for both types of disease can be implemented. Cancer Res; 76(22); 1–9. �2016 AACR.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: American Association for Cancer Research
ISSN: 0008-5472
Funders: GlaxoSmithKline
Date of First Compliant Deposit: 14 November 2016
Date of Acceptance: 17 July 2016
Last Modified: 04 Jun 2017 09:30

Citation Data

Cited 54 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item